Use in pregnancy: Zoledronic acid should not be used during pregnancy. There are no studies in pregnant women using zoledronic acid. In reproductive studies, zoledronic acid was teratogenic in the rat at SC doses ≥0.2 mg/kg. If the patient becomes pregnant while taking Zinvel, the patient should be apprised of the potential harm to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant.
Use in lactation: It is not known whether zoledronic acid is excreted in human milk. Because many drugs are excreted in human milk, and because zoledronic acid binds to bone long term, zoledronic acid should not be administered to a nursing woman.