Zometa Caution For Usage

Instructions for Use and Handling: Zometa 4 mg/5 mL concentrate for solution and Zometa 4 mg/100 mL solution for infusion is for IV use only.
The 4 mg/5 mL concentrate from 1 vial (or the volume of the concentrate withdrawn as required) must be further diluted with 100 mL of calcium-free infusion solution (0.9% w/v sodium chloride solution or 5% w/v glucose solution).
The 4 mg/100 mL solution is a "ready-to-use" presentation which must not be further diluted or mixed with other infusion solutions except for patients with renal impairment. For reduced doses of this presentation in patients with mild and moderate renal impairment (see Dosage & Administration).
After aseptic dilution (or for reduced doses of the "ready-to-use" presentation), it is preferable to use the diluted product immediately. If not used immediately, the duration and conditions of storage prior to use are under the healthcare provider’s responsibility. The total time between dilution, storage in a refrigerator at 2-8°C and end of administration must not exceed 24 hrs. If refrigerated, the solutions must be allowed to reach room temperature before administration. (See Dosage & Administration).
Any unused solution should be discarded. Only clear solution free from particles and discoloration should be used.