AVELOX is contraindicated in persons with a history of hypersensitivity to moxifloxacin or any member of the quinolone class of antibacterials (see Precautions).
Both in preclinical investigations and in humans, changes in cardiac electrophysiology have been observed following exposure to moxifloxacin, in the form of QT prolongation. For reasons of drug safety, moxifloxacin is therefore contraindicated in patients with: Congenital or documented acquired QT prolongation; Electrolyte disturbances, particularly in uncorrected hypokalaemia; Clinically relevant bradycardia; Clinically relevant heart failure with reduced left-ventricular ejection fraction; Previous history of symptomatic arrhythmias.
Moxiflaxacin should not be used concurrently with other drugs that prolong the QT interval (see also Interactions).