The following frequencies are estimated at the standard dose of 50 micrograms twice daily. Frequencies at the higher dose of 100 micrograms twice daily have also been taken to account where appropriate.
Immune system disorders: Hypersensitivity reactions: Uncommon: Rash.
Very rare: Anaphylactic reactions including oedema and angioedema, bronchospasm and anaphylactic shock.
Metabolism and nutrition disorders: Very rare: Hyperglycaemia.
Nervous system disorders: Common: Tremor and headache (see Precautions).
The pharmacological side-effects of beta-2 agonist treatment, such as tremor and headache have been reported, but tend to be transient and to reduce with regular therapy. Tremor occurs more commonly when administered at doses higher than 50mcg twice daily.
Cardiac disorders: Common: Palpitations (see Precautions).
Uncommon: Tachycardia.
Tachycardia occurs more commonly when administered at doses higher than 50 mcg twice daily.
Very rare: Cardiac arrhythmias including atrial fibrillation, supraventricular tachycardia and extrasystoles.
Respiratory, thoracic and mediastinal disorders: Very rare: Oropharyngeal irritation and paradoxical bronchospasm (see Precautions).
Musculoskeletal and connective tissue disorders: Common: Muscle cramps.
Very rare: Arthralgia.
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