Zometa Caution For Usage

Concentrate for soln for infusion 4 mg/5 mL: Special Precautions for Disposal and other Handling: Prior to administration, 5.0 mL concentrate from one vial or the volume of the concentrate withdrawn as required, must be further diluted with 100 mL of calcium-free infusion solution (0.9% w/v sodium chloride solution or 5% w/v glucose solution).
Additional information on handling of Zometa, including guidance on preparation of reduced doses, is provided in Dosage & Administration.
Aseptic techniques must be followed during the preparation of the infusion. For single use only.
Only clear solution free from particles and discolouration should be used.
Healthcare professionals are advised not to dispose of unused Zometa via the domestic sewage system.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
Incompatibilities: To avoid potential incompatibilities, Zometa concentrate is to be diluted with 0.9% w/v sodium chloride solution or 5% w/v glucose solution.
This medicine product must not be mixed with calcium or other divalent cation-containing infusion solutions such as lactated Ringer's solution, and should be administered as a single intravenous solution in a separate infusion line.