The dosage of drugs known to be influenced by folic acid, for example phenytoin must be carefully monitored.
Folic acid may obscure pernicious anemia.
Pyridoxine can reduce the effect of levodopa.
It has been reported that folic acid is unstable in the presence of calcium salts such as calcium gluconate.
Some of the vitamins in LYOVEN may react with vitamin K bisulfite.
Direct addition of LYOVEN to intravenous fat emulsions is not recommended.