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Anaphylactic reactions may occur in allergic patients because of the presence of vitamin B1. Mild allergic reactions such as sneezing or mild asthma are warning signs that a further injection may give rise to anaphylactic shock.
Caution should be exercised when administering LYOVEN to patients who may be receiving vitamin A from other sources.
Following intravenous bolus injection, a moderate rise only in SGPT transaminases has been noted in some patients with active inflammatory enterocolitis. Increased levels are rapidly reversible following the interruption of administration. It is advisable to monitor transaminase levels in patient of this type. Also in the case of impaired kidney function, lipid soluble vitamin levels should be carefully monitored.
LYOVEN does not contain vitamin K. If this vitamin is required by the patient, it must be administered separately.
LYOVEN should not be given as a direct, undiluted intravenous injection as it may give rise to dizziness, faintness and possible tissue irritations.
Daily vitamin requirements must be calculated to avoid overdose and toxic effects, especially with regard to vitamins A and D in pediatric patients.
In patients for whom total parenteral will be continued for long periods of time, vitamins A, C, D and folic acid blood levels should be monitored.
Pregnancy and lactation.
It is recommended that this product should not be used in pregnancy. Since vitamins are known to be excreted in breast milk, this product should also not be used in women who are breastfeeding.
