Discontinue use if serum Na level falls below LLN range. Interrupt & reassess treatment in acute intercurrent illnesses characterised by fluid &/or electrolyte imbalance eg, systemic infections, fever, gastroenteritis. Not recommended in coexistent conditions associated w/ CV symptoms & fluid overload; patients suspected of lithium-induced nephrogenic diabetes insipidus. Consider severe bladder dysfunction & outlet obstruction prior to treatment. Cystic fibrosis, CHD, HTN, pre-eclampsia. Limit fluid intake from 1 hr before until 8 hr after administration. Monitor serum Na in concomitant use w/ TCAs, SSRIs, chlorpromazine, diuretics, carbamazepine, sulfonylurea antidiabetics eg, chlorpropamide; NSAIDs. Concomitant use w/ thiazide or loop diuretics. Chronic renal disease. Pregnancy. Elderly ≥65 yr.
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