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Hypersensitivity to the active substances or to any of the excipients.
Habitual or psychogenic polydipsia (resulting in a urine production exceeding 40 ml/kg/24 hours).
Known or suspected cardiac insufficiency or other conditions associated with fluid overload, sufficient to require treatment with diuretics, including a history of such conditions.
Moderate and severe renal insufficiency (creatinine clearance below 50 ml/min).
Known history of hyponatremia.
Syndrome of inappropriate ADH secretion (SIADH).
