View Volibris overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food: Swallow whole, do not chew/crush/split tab.
Contraindications
Hypersensitivity to ambrisentan & soya. Idiopathic pulmonary fibrosis w/ or w/o secondary pulmonary HTN. Baseline values of hepatic aminotransferases ≥3x ULN. Severe hepatic impairment w/ or w/o cirrhosis. Women of childbearing potential who are not using reliable contraception. Pregnancy & lactation.
Hypersensitivity to ambrisentan & soya. Not recommended in patients w/ clinically significant anaemia. Not to be initiated in patients w/ ALT &/or AST baseline values >3x ULN. Peripheral oedema; pulmonary veno-occlusive disease. Patients w/ WHO functional class IV PAH. Monitor liver function, Hb &/or haematocrit levels during treatment. Concomitant use w/ rifampicin. May cause allergic reaction due to azo colouring agent. Not to be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive or operate machinery. Not to be initiated in severe hepatic impairment. Severe renal impairment. Not to be initiated in women of childbearing potential. Childn & adolescents <18 yr.
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