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There is no experience in PAH patients of ambrisentan at daily doses greater than 10 mg. In healthy volunteers, single doses of 50 and 100 mg (5 to 10 times the maximum recommended dose) were associated with headache, flushing, dizziness, nausea and nasal congestion.
Due to the mechanism of action, an overdose of ambrisentan could potentially result in hypotension (see Pharmacology: Toxicology: Preclinical safety data under Actions). In the case of pronounced hypotension, active cardiovascular support may be required. No specific antidote is available.
