Schizophrenia & other psychotic disorders; maintenance of clinical improvement & prevention of relapse. Manic or mixed episodes associated w/ bipolar disorder w/ or w/o psychotic features. Monotherapy for acute treatment of manic or mixed episodes associated w/ bipolar I disorder. Adjunct to lithium or valproate for maintenance treatment of bipolar I disorder.
Adult Initially 40 mg bd. may be adjusted depending on patient status up to max: 80 mg bd. Maintenance of bipolar I Continue w/ same stabilized dose w/in range: 40-80 mg bd.
View Zeldox overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food: Swallow whole, do not chew/crush/open.
Contraindications
Hypersensitivity. Known QT-interval prolongation including congenital long QT syndrome; recent MI; uncompensated heart failure; cardiac arrhythmias requiring treatment w/ class IA & III antiarrhythmic drugs.
Discontinue use if NMS & severe cutaneous ARs occur. Not for dementia-related psychosis. Increased risk of CVA in dementia population. Mild to moderate QT-interval prolongation; VTE; tardive dyskinesia; falls; history of seizures; risk factors for stroke; priapism; hyperprolactinemia; hyperglycemia, DM; history or at risk of sleep apnoea. Concomitant use w/ other CNS drugs, alcohol. Not to be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Severe hepatic impairment. Women of childbearing potential should use effective contraception. Pregnancy. Not to be used during lactation. Childn <18 yr.
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