Salbutamol like other beta-agonists, may cause fine tremors of the skeletal muscles specially the hands, nervous tension, hyperacidity, restlessness, headaches, increased heart rate, palpitations, tachycardia, hyperglycemia, peripheral vasodilation and rarely muscle cramps. The said effects which are common to all symphatomimetic drugs are dose-related.
Potentially serious hypokalemia and myocardial ischemia can occur in large doses. Hypersensitivity reactions including paradoxical bronchospasms, angioedema, urticaria, hypotension and collapse may also occur.