Activent Contraindications

Salbutamol (Activent) should not be used in patients with history of hypersensitivity to salbutamol.
Salbutamol should not be administered concomitantly with other sympathomimetic agents as it may cause adverse effects on the cardiovascular system.
Caution should be exercised in administering salbutamol to patients with thyroid disorders, myocardial insufficiency, arrhythmias, hypertension, susceptibility to QT-interval prolongation and diabetes mellitus.
The bronchodilator effects of beta-agonist are opposed by non-cardioselective beta-blockers. Non-cardioselective beta blocker are contraindicated in asthmatic patients as they may cause serious bronchoconstriction. Normally, no adverse interaction occurs between beta-agonist bronchodilators and cardioselective beta blocker; however, bronchospasm can occur in asthmatic patients particularly if high doses are used.
As the use of salbutamol with corticosteroids, diuretics or xanthines increases the risk of hypokalemia, monitoring of potassium concentrations is recommended in severe asthma where such combination therapy is common.