Ampimax Caution For Usage

Compatibility, Reconstitution and Stability: To be stored at a temperature not exceeding 25°C prior to reconstitution. When concomitant therapy with aminoglycosides is indicated, combination with aminoglycosides should be reconstituted and administered separately, due to the in vitro inactivation of aminoglycosides by any of the amino-penicillins.
Directions for Use: General Dissolution Procedure: Sterile powder for intravenous and intramuscular use may be reconstituted with any of the compatible diluents described in this monograph. Solutions should be allowed to stand after dissolution to allow any foaming to dissipate in order to permit visual inspection for complete solubilization.
Preparation for Intravenous use: Sterile powder may be reconstituted directly to the desired concentration using any of the following parenteral diluents. Reconstitution at the specified concentrations, with these diluents provides stable solutions for the time periods indicated in the following table. After the indicated time periods, any unused portions of solutions should be discarded. Initially the contents of vials may be dissolved in 3 mL of Sterile Water for Injection. This solution should be further diluted with an infusion medium to give a final concentration of around 15 to 30 mg/mL. The reconstituted solution should be infused over a period of 15 to 30 minutes.
Preparation for Intramuscular Use: The contents of 1.5 g vial should be reconstituted with 3 mL Sterile Water for Injection and for 0.75 g vial 2 mL of Sterile Water for Injection should be used.
NOTE: Use only freshly reconstituted solutions and administer within half hour after preparation. (There is sufficient excess present to allow withdrawal and administration of the stated volumes). Do not allow to freeze. (See Table 2.)

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