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Pregnancy: There is no adequate information on the use of paclitaxel in pregnant women. Paclitaxel has been shown to be embryotoxic and foetotoxic in rabbits, and to decrease fertility in rats.
As with other cytotoxic drugs, paclitaxel may cause fetal harm, and is therefore contraindicated during pregnancy. Women should be advised to avoid becoming pregnant during therapy with paclitaxel, and to inform the treating physician immediately should this occur. Female and male patients of fertile age, and/or their partners should use contraception for at least 6 months after treatment with paclitaxel.
Breast-feeding: Paclitaxel is contraindicated during lactation. It is not known whether paclitaxel is excreted in human milk. Breastfeeding should be discontinued for the duration of therapy.
