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Concomitant administration of substances with a negative chronotropic or dromotropic effect eg, nonsteroidal and anti-inflammatory agents can reduce the therapeutic effect of clonidine.
Central Nervous System Depressants: Clonidine may be additive with or may potentiate the action of other CNS depressants eg, opiates or other analgesics, barbiturates, or other sedatives, anesthetics or alcohol. Concomitant administration of opiate analgesics with clonidine may also potentiate the hypotensive effects of clonidine.
Psychotherapeutic Agents: Tricyclic antidepressants (eg, imipramine, desipramine) may block the antihypertensive effects of clonidine and possibly life-threatening elevations in blood pressure may occur.
Beta-Adrenergic Blocking Agents: Concomitant administration with clonidine may result in attenuation or reversal of antihypertensive effect and potentially life-threatening increases in blood pressure.
