Cohart Adverse Reactions

Losartan Potassium: Adverse effects include dizziness and dose related orthostatic hypotension. Hypotension may occur particularly in patients with volume depletion (for example those who have received high-dose diuretics). Losartan potassium may cause hyperkalemia in patients with renal disease. Other adverse effects that have been reported with angiotensin II receptor antagonist include respiratory-tract disorder, back pain, gastrointestinal disturbances, fatigue, and neutropenia.
Hydrochlorothiazide: Thiazide diuretics may cause a number of metabolic disturbances especially at high doses. They may provoke hyperglycemia and glycosuria in diabetic and other susceptible patients. They may cause hyperuricemia and precipitate attacks of gout in some patients. Administration of hydrochlorothiazide may be associated with electrolyte imbalances including hypochloremic alkalosis, hyponatremia, and hypokalemia. Hypokalemia intensifies the effect of digitalis on cardiac muscle and administration of digitalis or its glycosides may be temporarily suspended. Patients with cirrhosis of the liver are particularly at risk from hypokalaemia.