Sign Out
It must not be given to pregnant women because it crosses the placenta and is distributed in breast milk. Hydrochlorothiazide is not effective in patients with creatine clearance of less than 30 mL per minute and thus should not be given to patients with severe renal impairment or anuria. It is also contraindicated with Addison's disease.
Thiazide can reduce urinary excretion of calcium, sometimes resulting in mild hypercalcemia and is therefore contraindicated to patients with pre-existing hypercalcemia.
