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Pharmacology: Mechanism of Action: Clindamycin has an antimicrobial spectrum similar to that of lincomycin but its activity against sensitive organisms is greater.
Pharmacokinetics: Clindamycin is widely distributed in body fluids and tissues including bone but it does not reach the cerebrospinal fluid in significant concentrations.
Clindamycin diffuses across the placenta into the fetal circulation and has been reported to appear in breast milk.
High concentrations occur in bile. About 10% of a dose is excreted in the urine as active clindamycin and about 4% in the faeces; the remainder is inactivated in the liver.
Increased urinary recovery of clindamycin has been reported in patients with liver disease. It is not effectively removed from the blood by dialysis.
