Dalamed Special Precautions

General: Review of experience to date suggests that a subgroup of older patients with associated severe illness may tolerate diarrhea less well. When clindamycin is indicated in these patients, they should be carefully monitored for change in bowel frequency.
Clindamycin HCl should be prescribed with caution in individuals with history of gastrointestinal disease, particularly colitis.
Clindamycin HCl should be prescribed with caution in atopic individuals.
Indicated surgical procedures should be performed in conjunction with antibiotic therapy.
The use of clindamycin HCl occasionally results in overgrowth of nonsusceptible organisms particularly yeasts.
Should superinfections occur, appropriate measures should be taken as indicated by the clinical situation.
Clindamycin dosage modification may not be necessary in patients with renal disease. In patients with moderate to severe liver disease, prolongation of clindamycin half-life has been found. However, it was postulated from studies rarely occur. Therefore dosage modification in patients with liver enzyme determinations should be made when treating patients with severe liver disease.