Dalamed Warnings

Pseudomembranous colitis has been reported with nearly all antibacterial agents, including clindamycin, and may range in severity from mild to life-threatening.
Therefore it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Because clindamycin therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections less toxic antimicrobial agents are inappropriate as described. It should not be used in patients with non-bacterial infections such as most bacterial agents alters the normal flora of the colon and may permit overgrowth of clostridia.
Studies indicate that a toxin produced in Clostridium difficile is one primary cause of antibiotic-associated colitis.
After diagnosis of pseudomembranous colitis usually severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation, and treatment with an antibacterial drug clinically effective against Clostridium difficile colitis.
Diarrhea, colitis and pseudomembranous colitis have been observed to begin up to several weeks following cessation of therapy with clindamycin.
Usage in Meningitis: Since clindamycin does not diffuse adequately into the cerebrospinal fluid, the drug should not be used in the treatment of meningitis.