Deperin Contraindications

Sertraline Tablets are contraindicated in patients with a known hypersensitivity to sertraline.
Sertraline should not be used in combination with Monoamine Oxidase Inhibitor (MAOI).
Cases of serious and sometimes fatal reactions have been reported in patients receiving an SSRI and have been combination with MAOI and patients who have recently discontinued an SSRI and have been started on a MAOI. Sertraline may be started on a MAOI. Sertraline may be started 14 days after discontinuing treatment with an irreversible MAOI and at least one day after discontinuing treatment with moclobemide. At least 14 days should elapse after discontinuing Sertraline treatment before starting a MAOI.
Symptoms of a drug interaction with a MAOI include: hyperthermia, rigidity, myoclonus, automatic instability with possible rapid fluctuations of vital signs, mental status changes that include confusion, irritability and extreme agitation progressing to delirium and coma.