Deperin Dosage/Direction for Use

It is given orally as sertraline hydrochloride as a single dose in the morning or evening. Doses are expressed in terms of the base; sertraline hydrochloride 56 mg is equivalent to about 50 mg of sertraline.
In the treatment of depression, the usual initial dose of sertraline is 50 mg daily increased, if necessary, in increments of 50 mg at intervals of at least a week to a maximum of 200 mg daily.
The usual initial dose of sertraline in obsessive-compulsive disorder is 50 mg daily. In the treatment of panic disorder with or without agoraphobia, social anxiety disorder, and post-traumatic stress disorder, the usual initial dose is 25 mg daily increased after one week to 50 mg daily. Thereafter, doses in all these disorders may be increased, if necessary, in increments of 50 mg at intervals of at least a week to a maximum of 200 mg daily.
Sertraline is also given for the treatment of obsessive-compulsive disorder in children and adolescents aged 6 years and over. In children aged 6 to 12 years the usual initial dose is 25 mg once daily; adolescents may be started on 50 mg once daily. Increases in doses, if necessary, are similar to those in adults; however, the lower body-weights of children should be considered in order to avoid excessive doses. In the treatment of premenstrual dysphoric disorder, sertraline is given in an initial dose of 50 mg daily either throughout the menstrual cycle or during the luteal phase only, as appropriate. Doses may be increased by 50 mg each menstrual cycle up to a maximum of 150 mg daily for continuous dosing or 100 mg daily when dosing during the luteal phase only. Those patients who require 100 mg daily during luteal phase-only dosing should initially be given 50 mg daily for the first 3 days of each luteal phase dosing period. Once the optimal therapeutic response is obtained dosage should be reduced to the lowest effective level for maintenance. Reduced doses are recommended in patient with hepatic impairment. Sertraline should be withdrawn gradually to reduce the risk of withdrawal symptoms.