Deperin Drug Interactions

Monoamine oxidase inhibitors: See Contraindications.
Centrally active medication: SSRIs have the potential to interact with tricyclic antidepressants leading to an increase in plasma levels of the tricyclic antidepressant.
Pimozide: Increased pimozide levels have been demonstrated in a study of a single low dose pimozide (2 mg) with sertraline coadministration. These increased levels were not associated with any changes ECG.
Lithium and Tryptophan: Co-administration of sertraline with lithium resulted in an increase in tremor relative in to placebo, indicating a possible pharmacodynamic interaction. There have been other reports of enhanced effects when SSRIs have given with lithium tryptophan and therefore the concomitant use of SSRIs with these drugs should be undertaken with caution.
Serotonergic drugs: Serotonergic drugs, such as tramadol, sumatriptan or fenfluramine, should not be used concomitantly with sertraline, due to a possible enhancement of 5-HT associated effects.
Warfarin: Co-administration of sertraline (200 mg daily) with warfarin may results in a small but statistically significant increase in prothrombin time.
St. John's Wort: Concomitant use of the herbal remedy St. John's Wort (Hypericum perforatum) in patients receiving SSRIs should be avoided since there is a possibility of serotonergic potention
Co-administration with cimetidine caused a substantial decrease in sertraline clearance.