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Contraindicated in patients with known hypersensitivity to Mefenamic acid, in patients with active peptic ulcer or inflammatory bowel disease, and in patients with hepatic and renal impairment. Cross sensitivity with aspirin and other NSAIDS may occur and elicit allergic symptoms such as bronchoconstriction.
Absolute contraindications: Not to be given to those patients who have history of: Stroke cerebrovascular accident (CVA); Heart attack: Myocardial infarction (MI); Coronary artery bypass graft (CABG); Uncontrolled hypertension; Congestive heart failure (CHF) NYHA II-IV.
