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Pharmacology: Mefenamic acid has demonstrated analgesic, antipyretic and anti-inflammatory effects. In tests of analgesia, it displays a central as well as a peripheral action. These actions appear to be via inhibition of prostaglandin-forming cyclo-oxygenase.
Following a single oral dose, Mefenamic acid is fairly rapidly absorbed.
Peak concentrations in blood plasma are observed at 2 to 4 hours after ingestion. Approximately 50% of the dose of the drug is excreted in the urine as conjugated metabolites; about 20% is recovered in the feces during the first three days after administration.
