Glimep Drug Interactions

Numerous interactions have been reported with the sulfonylureas, largely representing either pharmacokinetics interactions (due to the displacement of the antidiabetic from plasma proteins or alteration in its metabolism or excretion) or pharmacological interactions with drugs having an independent effect on blood glucose.
A diminished hypoglycemic effect, possibly requiring an increased dose of sulfonylurea, has been seen or might be expected on theoretical grounds with adrenaline, aminogluthimide, chlorpromazine, corticosteroids, diazoxide, oral contraceptives, rifampicins, and thiazide diuretics.
An increased hypoglycemic effect has occurred or might be expected with ACE inhibitors, alcohol, allopurinol, some analgesics (notably azapropazone, phenylbutazone, and the salicylates), azole, antifungal, chloramphenicol, cimetidine, clofibrate and related compounds, coumarin, anticoagulants, heparin, MAOIs, octreotide, ranitidine, sulfinpyrazone, sulfonamides, tetracyclines, tricyclic antidepressants, and thyroids hormones. Beta blockers have been reported both to increase hypoglycaemia and to mask the typical sympathetic warning signs. There are sporadic and conflicting reports of a possible interactions with calcium-channel blockers, but overall any effect seems to be of little clinical significance. In addition to producing hypoglycemia alcohol can interact with chlorpropamide to produce an unpleasant flushing reaction. Such an effect is rare with other sulfonylureas and alcohol.