Glimep Special Precautions

In the initial weeks of treatment, the risk of hypoglycemia may be increased and necessitate especially careful monitoring.
Factors favoring hypoglycemia include: Unwillingness or (more commonly in order patients) incapacity of the patient to cooperate; undernourishment, irregular mealtimes or skipped meals; imbalance between physical exertion and carbohydrate intake; alterations of diet; consumption of alcohol, especially in combination with skipped meals; impaired renal function; overdosage with glimepiride; certain uncompensated disorders of the endocrine system affecting carbohydrate metabolism or counter-regulation of hypoglycemia (eg, in certain disorders of thyroids function and in anterior pituitary or Corticoadrenal insufficiency); concurrent administration of certain other medicines.
Those symptoms of hypoglycemia which reflect the body's adrenergic counter-regulation may be milder or absent where hypoglycemia develops gradually, in the elderly, and where there is autonomic neuropathy or where the patient is receiving concurrent treatment with beta blockers, clonidine, reserpine, guanethidine or other sympatholytic drugs.
Hypoglycemia can almost always be promptly controlled by immediate intake of carbohydrates (glucose or sugar).
Effect on the Ability to Drive or Operate Machinery: Alertness and reactions may be impaired due to hypo- or hyperglycemia, especially when beginning or after altering treatment, or when glimepiride is not taken regularly. This way, for example, affect the ability to drive or operate machinery.