Globantin Dosage/Direction for Use

Clavulanate Potassium and Amoxicillin 1.2 g powder for injection can be reconstituted by dissolving 20 mL Water for Injection BP. When a diluent is added a transient ink coloration or slight opalescence will be observed where after, a pale yellow fluid. For intravenous infusion, the reconstituted vial should be further diluted with the desired volume of a suitable infusion fluid. (See Table 1.)

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Clavulanate Potassium and Amoxicillin vials should not be reconstituted or mixed with: Dextrose solution, Sodium bicarbonate solution for injection, Protein hydrolysates or other proteinaceous fluids, Blood or plasma, Intravenous lipids.
However, the reconstituted solution may be injected into the drip tubing of infusion fluids containing glucose, bicarbonate and dextran over a period of 3-4 minutes.
Note: Clavulanate Potassium and Amoxicillin vials are not suitable for intramuscular or subcutaneous administration. The reconstituted vials can be administered intravenously by injection (2 minutes) or slow intravenous infusion (30 minutes).
DOSAGES: Adult (Intravenous): For severe infections of the respiratory tract, urinary tract and skin and soft tissue requiring parenteral therapy initially 1 Clavulanate Potassium and Amoxicillin 1.2 g vial containing the equivalent of 1000 mg of AMOXICILLIN and 200 mg clavulanic acid can be administered intravenously 6 to 8 hourly by intravenous injection (2 minutes) or intravenous infusion (30 minutes) until condition settles followed by oral therapy Clavulanate Potassium and Amoxicillin 375 tablets at the recommended dose. If no response has occurred within 48 hours therapy must be reviewed.
Intravenous treatment with Clavulanate Potassium and Amoxicillin should not extend beyond 10 days without review and the total daily administration of clavulanic acid should not exceed 800 mg. Treatment can be continued with Clavulanate Potassium and Amoxicillin 375 tablets orally where appropriate after a satisfactory therapeutic response has been obtained.
Adult: See Table 2.

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Children: Insufficient evidence exists at present to recommend an intravenous dosage in children.
Or as prescribed by the physician.