Gouter Drug Interactions

Increased risk of myopathy and rhabdomyolysis with statins, fibrates, digoxin, ciclosporin. Increased plasma concentration with cimetidine and tolbutamide. May cause reversible malabsorption of vitamin B12. Concomitant use with phenylbutazone may increase risk of leucopenia, thrombocytopenia or bone marrow depression. NSAIDs may increase risk of gastrointestinal ulceration or haemorrhage. Reduced efficacy of prophylactic gout therapy with cytolytic antineoplastic agents.
Potentially Fatal: Increased risk of toxicity with CYP3A4 or P-gp inhibitors such as macrolides (e.g., clarithromycin, erythromycin), HIV protease inhibitors (e.g., ritonavir, atazanavir), Ca²⁺ channel blockers (e.g., verapamil, diltiazem), ketoconazole, itraconazole, voriconazole, ciclosporin, disulfiram.
Food Interaction: Increased plasma concentrations with grapefruit juice. Increased blood uric acid levels and risk of gastrointestinal toxicity with alcohol.
Laboratory Interference: May cause false-positive results in urine tests for erythrocytes or hemoglobin levels. May interfere with urinary determination of 17-hydroxycorticosteroids using the Reddy, Jenkins and Thorn procedures.