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Colchicine should be given with great care to old and debilitated patients who may be particularly susceptible to cumulative toxicity. It should also be used with caution in patients with cardiac, hepatic, renal or gastrointestinal disease. Care should also be exercised if treating pregnant patients since Colchicine is known to be teratogenic in animals and there have also been some suggestions of a risk of fetal chromosome damage in humans.
Colchicine should not be administered by subcutaneous or intramuscular injection as it causes severe local irritation.
