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Pyridoxine (Vitamin B6): Nitrofurantoin may increase pyridoxine level which could induce sensory neuropathy.
High daily doses of vitamin B6 can decrease phenytoin and phenobarbital serum concentration.
Vitamin B6 can reduce the effectiveness of altretamine (hexamethylmelamine).
Vitamin B6 can reduce or abolish the effect of levodopa through increased peripheral metabolism by dopa-decarboxylase.
Isoniazid may reduce plasma vitamin B6 levels.
Cyanocobalamin (Vitamin B12): Intestinal absorption of vitamin B12 can be reduced by, colchicine, aspirin, proton pump inhibitors and H2-receptor antagonists.
Prolonged metformin use can induce vitamin B12 deficiency.
Contraceptive use may lower serum levels of vitamin B12 most likely due to redistribution rather than depletion.
dl-alpha Tocopherol acetate (Vitamin E): Vitamin E can enhance the effect of warfarin and aspirin.
Vitamin E may decrease oral cyclosporine levels.
Statin may reduce plasma concentration of vitamin E.
Orlistat may reduce intestinal absorption of vitamin E by inhibition of gastrointestinal lipase.
