HTN Initially 150 mg once daily, increased necessary to 300 mg once daily. Renal disease in HTN type 2 DM Initially 150 mg once daily increased to 300 mg once daily. Haemodialysis & elderly >75 yr Initially 75 mg once daily.
Potentiated by drugs & other agents that lower BP. Additive hyperkalaemic effect w/ K supplements, K-sparing diuretics or other drugs that can cause hyperkalaemia. CYP450 isoenzymes.
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