Pharmacology: Pharmacokinetics: Irbesartan is rapidly absorbed from the gastrointestinal tract with an oral bioavailability of 60 to 80%. Peak plasma concentrations of Irbesartan occur 1.5 to 2 hours after an oral dose. It undergoes some metabolism in the liver. primarily by the cytochrome P450 isoenzvme CYP2C9, to inactive metabolites. It is excreted as unchanged drug and metabolites in the bile and in urine; about 20% of an oral or intravenous dose is excreted in the urine, with less than 2% as unchanged drug. The terminal elimination half life is about 11 to 15 hours.
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