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The antihypertensive effects of irbesartan may be potentiated by drugs or other agents that lower blood pressure.
An additive hyperkalaemic effect is possible with potassium supplements, potassium-sparing diuretics, or other drugs that can cause hyperkalaemic; Irbesartan and potassium-sparing diuretics should not generally be given together.
Irbesartan and some other angiotensin II receptor antagonists are metabolized by cytochrome P450 isoenzymes and interactions may occur with drugs that affect these enzymes.
