Kabimidine Adverse Reactions

Overall, the most frequently observed adverse events included hypotension, hypertension, bradycardia, dry mouth and nausea. Other reported adverse reactions include, amongst others, fever, pain, rigors, blood pressure fluctuations, arrhythmia, AV Block, cardiac arrest, extrasystoles, atrial fibrillation, T-wave inversion, tachycardia, edema, cyanosis, angina pectoris, myocardial ischemia, pulmonary edema, dizziness, headache, neuralgia, neuritis, speech disorder, abdominal pain, diarrhea, vomiting, ascites, eructation, acidosis, hyperkalemia, thirst, lactic acidosis, hyperglycemia, hypervolemia, muscle weakness, syncope, neuropathy, paresthesia, paresis, agitation, confusion, delirium, hallucination, illusion, anxiety, depression, nervousness, anemia, urinary retention, apnea, bronchospasm, dyspnea, hypercapnia, hypoventilation, hypoxia, pulmonary congestion, pulmonary hypertension, bronchial obstruction, coughing, emphysema, hemoptysis, pneumothorax, respiratory depression, increased sputum, stridor, increased sweating, erythematous rash, photopsia and abnormal vision.
Investigations: Abnormalities of ECG, T-wave inversion, and an increase in GGT, SGOT, SGPT, alkaline phosphatase, BUN, NPN, or a decreased prothrombin level may be observed.
Drug Abuse and Dependence: The dependence potential of Dexmedetomidine has not been studied in humans. However, since studies in rodents and primates have demonstrated that Dexmedetomidine exhibits pharmacologic actions similar to those of clonidine, it is possible that Dexmedetomidine may produce a clonidine-like withdrawal syndrome upon abrupt discontinuation.
ADR Reporting Statement: Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. For suspected adverse drug reaction, report to FDA: www.fda.gov.ph. Immediately seek medical attention if adverse drug reaction occurs.