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General: In vitro studies indicate the clinically relevant cytochrome P450 mediated drug interactions are unlikely.
Anesthetics/Sedatives/Hypnotics/Opioids: Co-administration of Dexmedetomidine Hydrochloride is likely to lead to an enhancement of effects with anesthetics, sedatives, hypnotics and opioids. Due to pharmacodynamic effects, when co-administered with Dexmedetomidine Hydrochloride, a reduction in dosage with these agents may be required. Additionally, in situations where other
vasodilators or negative chronotropic agents are administered, co-administration of Dexmedetomidine could have an additive pharmacodynamic effect and should be administered with caution and careful titration. Clinical events of bradycardia or hypotension may be potentiated when Dexmedetomidine is used concurrently with propofol or Midazolam. Therefore, consider a reduction in the dose of Midazolam or propofol.
