Kanosole Mechanism of Action

Pharmacology: Triamcinolone is a corticosteroid with mainly glucocorticoid activity, which has potent anti-inflammatory and immunosuppressive effects, at least party through inhibition of the release of various cytokines. It also has profound metabolic affects: blood glucose concentrations are maintained or increased by a decrease in peripheral glucose utilization and an increase in gluconeogenesis; glycogen deposition, protein breakdown, and lipolysis are increased, and effects on calcium uptake and excretion lead to a decrease in body calcium stores.
Pharmacokinetics: Triamcinolone is readily absorbed from sites of local administration and is rapidly distributed to all body tissues. It crosses the placenta to varying degrees and may be excreted in small amounts in breast milk. In the circulation, it is extensively bound to plasma proteins, mainly to globulin and less so to albumin. The corticosteroid-binding globulin (transcortin) has high affinity but low binding capacity, while albumin has low affinity but large binding capacity. The plasma half-life of Triamcinolone is 1 to 2 hours.
Triamcinolone is metabolized mainly in the liver but also in other tissues, and are excreted in the urine.