Kardiostan Dosage/Direction for Use

Hypertension: Usual Dose: 50 mg. This may be increased to 100 mg/day given as 1 or 2 doses, when necessary. The dose may be adjusted based on blood pressure measures of the patient.
Patients with Diabetic Nephropathy: Initial Dose: 50 mg/day and may be increased to 100 mg depending on the patient's response to Kardiostan.
Hepatic Impairment: Administration of losartan in patients with cirrhosis showed a significant increase of levels of losartan and its active metabolite in the blood. Initial dose for patients with hepatic impairment or history of such is 25 mg.
In the absence of hepatic insufficiency among elderly, losartan may be given 50 mg daily. Dose may be increased to 100 mg/day given in 2 doses, when necessary.
Renal Impairment: In cases of moderate to severe renal impairment, intravascular or salt depletion eg, those in patients undergoing hemodialysis or under treatment with diuretics, the initial dose may be reduced to 25 mg/day.
In a recent study, the use of losartan 0.75 mg/kg (maximum of 50 mg) in hypertensive children 6-16 years proved to be beneficial in reducing diastolic blood pressure within 3 weeks. Losartan is generally well tolerated when given up to a dosage of 1.44 mg/kg/day (maximum of 100 mg).
Administration: Administration of losartan with food does not significantly affect the absorption of Kardiostan. Thus, it may be given with or without food.