Lacibloc Description

Each Film-coated Tablet contains: Lacidipine 4 mg, 6 mg.
The main use of calcium-channel blockers is in the management of angina pectoris and hypertension; some are also employed in cardiac arrhythmias.
Calcium-channel blockers, also known as calcium antagonists, calcium-entry blockers, and slow-channel blockers inhibit the cellular influx of calcium which is responsible for maintenance of the plateau phase of the action potential. Thus calcium-channel blockers primarily affect tissues in which depolarization is dependent upon calcium rather than sodium influx, and these include vascular smooth muscle, myocardial cells, and cells within the sino-atrial (SA) and atrioventricular (AV) nodes. The main actions of the calcium-channel blockers include dilatation of coronary and peripheral arteries and arterioles with little or no effect on venous tone, a negative inotropic action, reduction of heart rate, and slowing of AV conduction. However, the effects of individual drugs, and therefore their uses, are modified by their selectivity of action at different tissue sites and by baroreceptor reflexes.