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Diazepam: The co-administration of diazepam with olanzapine potentiated the orthostatic hypotension observed with olanzapine.
Cimetidine and Antacids: Single doses of cimetidine (800 mg) or aluminum- and magnesium- containing antacids did not affect the oral bioavailability of olanzapine.
Alcohol: Ethanol (45 mg/70 kg single dose) did not have an effect on olanzapine pharmacokinetics. The co-administration of alcohol (i.e., ethanol) with olanzapine potentiated the orthostatic hypotension observed with olanzapine.
Potential for Olanzapine to Affect Other Medicinal Products: Olanzapine may antagonise the effects of direct and indirect dopamine agonists.
General CNS activity: The concomitant use of olanzapine with anti-Parkinsonian medicinal products in patients with Parkinson's disease and dementia is not recommended.
