Nasofree Mechanism of Action

Pharmacology: Structurally and pharmacologically related to naphazoline, tetrahydrozoline, and xylometazoline.
Directly stimulates α-adrenergic receptors; exerts little or no effect on β-adrenergic receptors.
Constricts dilated arterioles, reduces nasal blood flow and congestion, and opens obstructed eustachian ostia. Temporarily, relieves nasal and conjunctival congestion following topical application.
Pharmacokinetics: Absorption: Bioavailability: Occasionally, absorption may be sufficient to produce systemic effects.
Onset: Following intranasal administration, local vasoconstriction usually occurs within 5-10 minutes.
Following ocular administration, local vasoconstriction usually occurs within minutes.
Duration: Following intranasal administration, local vasoconstriction persists for 5-6 hours, with gradual decline over the next 6 hours.
Following ophthalmic administration, local vasoconstriction persists for up to 6 hours.