Nasofree

Oxymetazoline hydrochloride.

Pharmacology: Structurally and pharmacologically related to naphazoline, tetrahydrozoline, and xylometazoline.
Directly stimulates α-adrenergic receptors; exerts little or no effect on β-adrenergic receptors.
Constricts dilated arterioles, reduces nasal blood flow and congestion, and opens obstructed eustachian ostia. Temporarily, relieves nasal and conjunctival congestion following topical application.
Pharmacokinetics: Absorption: Bioavailability: Occasionally, absorption may be sufficient to produce systemic effects.
Onset: Following intranasal administration, local vasoconstriction usually occurs within 5-10 minutes.
Following ocular administration, local vasoconstriction usually occurs within minutes.
Duration: Following intranasal administration, local vasoconstriction persists for 5-6 hours, with gradual decline over the next 6 hours.
Following ophthalmic administration, local vasoconstriction persists for up to 6 hours.

For relief of nasal congestion associated with acute or chronic rhinitis, common colds, sinusitis, hay fever and other allergies; to reduce swelling and facilitate visualization of nasal and pharyngeal membranes prior to surgery or diagnostic procedures; epistaxis; vasomotor rhinitis; non-allergic rhinitis with eosinophilia syndrome (NARES).

The usual dose of Oxymetazoline HCl 0.05% solution is 2 to 3 sprays twice daily (every 10 to 12 hours) in each nostril or as prescribed by the physician. Do not use Oxymetazoline HCl more than directed and for more than 3 days.

Excessive dosage and/or prolonged or too frequent intranasal use of oxymetazoline may irritate nasal mucosa and, especially in children, may cause adverse systemic effects.

Nasal solution: transient burning, stinging, sneezing, increased nasal discharge or dryness of nasal mucosa.

Nasal Decongestants & Other Nasal Preparations

R01AA05 - oxymetazoline ; Belongs to the class of topical sympathomimetic agents used as nasal decongestants.

Non-Rx