Increased BP lowering effect w/ α-blockers, diuretics. Amlodipine: May increase plasma conc w/ potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir). May decrease plasma conc w/ CYP3A4 inducers [eg, anticonvulsants (eg, carbamazepine, phenobarb, phenytoin, fosphenytoin, primidone), rifampicin,
Hypericum perforatum]. Increased exposure to simvastatin, tacrolimus & cyclosporine. Olmesartan: Increased serum conc & toxicity of lithium. Increased risk of hypotension, hyperkalemia & changes in renal function including acute renal failure w/ angiotensin receptor antagonists, ACE inhibitors or aliskiren. May increase the worsening of renal function w/ NSAIDs. May attenuate antihypertensive effect w/ NSAIDs including COX-2 inhibitors. Reduced systemic exposure & peak plasma conc w/ colesevelam HCl.
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