Normetec Dosage/Direction for Use

Usual Adult Dose: The recommended dosage of Amlodipine/Olmesartan Medoxomil (Normetec) is 1 tablet daily, with or without food.
For convenience, patients receiving olmesartan medoxomil and amlodipine from separate tablets may be switched to Amlodipine/Olmesartan Medoxomil (Normetec) tablets containing the same component doses.
When clinically appropriate, direct change from monotherapy to the fixed combination may be considered. A step-wise titration of the dosage is recommended.
When necessary, a thiazide diuretic may be added to Amlodipine/Olmesartan Medoxomil (Normetec) therapy.
Elderly: No adjustment of the recommended dose is generally required for elderly patients.
Renal Impairment: No adjustment of the recommended dose is required for patients with mild to moderate impairment of renal function. The use of Amlodipine/Olmesartan Medoxomil (Normetec) in patients with severe renal impairment (creatinine clearance <20 mL/min) is not recommended.
Hepatic Impairment: Amlodipine/Olmesartan Medoxomil (Normetec) should be used with caution in patients with mild to moderate hepatic impairment. Amlodipine/Olmesartan Medoxomil (Normetec) is not recommended in patients with severe hepatic impairment.
Children: Amlodipine/Olmesartan Medoxomil (Normetec) is not recommended for use in children and adolescents below 18 years of age, due to a lack of data on safety and efficacy.