Normetec Description

Amlodipine/Olmesartan Medoxomil (Normetec) is a combination of the angiotensin II receptor antagonist olmesartan medoxomil and the calcium channel blocker amlodipine.
Olmesartan medoxomil, a prodrug, is hydrolyzed to olmesartan during absorption from the gastrointestinal tract.
Olmesartan medoxomil is chemically described as 2,3-dihydroxy-2-butenyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[p-(o-1H-tetrazol-5-ylphenyl) benzyl]imidazole-5-carboxylate, cyclic 2,3-carbonate. Its empirical formula is C₂₉H₃₀N₆O₆.
Amlodipine is chemically described as 3-Ethyl-5-methyl (±)-2-[(2-aminoethoxy) methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulphonate. Its empirical formula is C₂₀H₂₅ClN₂O₅·C₆H₆O₃S.
Amlodipine/Olmesartan Medoxomil (Normetec) is available for oral use as film-coated tablets in the following strengths: Amlodipine/Olmesartan Medoxomil (Normetec 5 mg/20 mg): Each film-coated tablet contains 6.944 mg of Amlodipine (as besilate) equivalent to 5 mg of Amlodipine Ph Eur and 20 mg of Olmesartan medoxomil equivalent to 20 mg of Olmesartan Ph Eur.
Amlodipine/Olmesartan Medoxomil (Normetec 5 mg/40 mg): Each film-coated tablet contains 6.944 mg of Amlodipine (as besilate) equivalent to 5 mg of Amlodipine Ph Eur and 40 mg of Olmesartan medoxomil equivalent to 40 mg of Olmesartan Ph Eur.
Amlodipine/Olmesartan Medoxomil (Normetec 10 mg/40 mg): Each film-coated tablet contains 13.888 mg of Amlodipine (as besilate) equivalent to 10 mg of Amlodipine Ph Eur and 40 mg of Olmesartan medoxomil equivalent to 40 mg of Olmesartan Ph Eur.