Patients w/ cerebrovascular disease, ischaemic heart disease including MI, renal impairment, occlusive peripheral vascular disorders eg, Raynaud's disease or those w/ a history of depression. Closely monitor patients for systemic effects after epidural use. Should be given slowly to avoid possible transient pressor effects. May impair ability to drive or operate machinery. Pregnancy & lactation.
Enhanced hypertensive effect by diuretics, other antihypertensives & drugs that cause hypotension. β-blockers. May antagonize hypotensive effect w/ TCA. May enhanced sedative effect by CNS depressants.
C02AC01 - clonidine ; Belongs to the class of imidazoline receptor agonists, centrally-acting antiadrenergic agents. Used in the treatment of hypertension.
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