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Symptoms: Clonidine has a wide therapeutic range. Manifestations of intoxication are due to generalized sympathetic depression and include pupillary constriction, lethargy, bradycardia, hypotension, hypothermia, somnolence including coma, respiratory depression including apnea. Paradoxic hypertension caused by stimulation of peripheral alpha1-receptors may occur.
Treatment: Careful monitoring and symptomatic measures.
