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Clonidine should be used with caution in patients with cerebrovascular disease, ischaemic heart disease including myocardial infarction, renal impairment, occlusive peripheral vascular disorders such as Raynaud's disease, or those with a history of depression. Clonidine causes drowsiness and patients should not drive or operate machinery where loss of attention could be dangerous. Systemic effects also occur after epidural use and patients should be closely monitored, particularly during the first few days of therapy.
Intravenous injections of clonidine should be given slowly to avoid a possible transient pressor effects especially in patients already receiving other antihypertensives such as guanethidine or reserpine.
